Endocrine Abstracts

Introduction: Posttraumatic stress disorder (PTSD) is anxious disorder that occurs following exposure to trauma. In the last two decades, numerous studies showed that dysregulation of hipothalamo–pituitary–adrenal axis (HPAA) is a core feature of the PTSD. Still, results are heterogeneous and often conflicted with one another. Therefore, we conducted strictly controlled study in order to characterize relationship between ACTH and cortisol secretion in patients with c...

Introduction: Metabolic syndrome (MS) is an independent risk factor of coronary artery disease (CAD). We investigated how influenced this risk is by the definition of MS, and whether the risk is greater than that conferred by its components.Methods: We analyzed 200 consecutive patients (35–79 years, mean 59.23±8.6, men 132, women 68) who underwent coronary angiography due to suspected myocardial ischemia. MS was obtained by several definitions:...

Adrenocortical carcinoma (ACC) is rare and aggressive malignancy with poor prognosis. Patients present with hormone excess or a local mass effect, or incidentally. ACC has undergone metastatic spread in 40–70% of patients at the time of diagnosis. Surgical removal is treatment of choice. Standard chemotherapy with mitotane has limited efficacy.The aim of this paper is to present the results of single tertiary center for diagnosis and treatment of AC...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1sy.) is a complex disease predisposing to a variety of multifocal neuroendocrine tumors (NET). Approximately 5% of pancreatic VIPomas and glucagonomas are associated with MEN1sy., most of them with metastases at diagnosis.Case report: A 15-year-old boy was admitted with primary hyperparathyroidism, pituitary microadenoma (6 mm) and suspected MEN1sy. His father had primary hyperparathyroidism...

Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome. In this study, we evaluated the degree of metabolic disorders in women with different PCOS phenotypes.Methods: We analyzed 162 women with PCOS (BMI: 24.9±6.1 kg/m2, age:25.6±5.6 years) diagnosed on the basis of ESHRE/ASRM criteria, and 39 women without PCOS who comprised the control group (CG; BMI: 21.4±4.1 kg/m...

Introduction: Polycystic ovary syndrome (PCOS) is associated with higher risk of cardiovascular disease. Measurement of carotid intima-media thickness (CIMT) is a simple non-invasive procedure for assessment and measurement of atherosclerotic plaque. It is a valuable tool for evaluation of cardiovascular disease risk, as increase in CIMT is associated with cardiovascular events, mainly stroke. In this study we evaluated association and influence of metabolic disturbances on CI...

Introduction: Leptin is an adipocyte-secreted hormone that plays a key part in energy homeostasis but also regulates reproductive, neuroendocrine, immune, and metabolic functions. Inflammatory cytokines may affect leptin secretion. Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues. The pathology of Gaucher disease pr...

Introduction: Pancreatic neuroendocrine tumors (PNETs) are generally clinically more indolent than adenocarcinomas. But relevant, clinically applicable prognostic survival factors still need to be more precisely defined.Aim: To identify survival factors in patients with PNETs.Methods: We analyzed 66 patients with PNETs (52.62±13.3 years old) treated at our department during 2003–2010. Patients with insulinomas were not in...

Introduction: Metabolic disturbances that are common in polycystic ovary syndrome (PCOS), represent a risk factor for cardiovascular disease. The aim of this study was to define contribution of obesity for the development of dyslipidemia and insulin resistance in PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. We evaluated 158 women with PCOS who were divided into two subgroups according to body mass index (BMI) cut off value 25 kg/m2</s...

Introduction: Women with polycystic ovary syndrome (PCOS) have higher prevalence of metabolic syndrome (MS) than healthy, age and BMI matched women. The aim of this study was to determine if novel abdominal adiposity index – lipid accumulation product (LAP), could predict MS in women with PCOS.Methods: PCOS was diagnosed using ESHRE/ASRM criteria. We evaluated 159 PCOS women (PCOS group: 24.9±6.2 kg/m2; 25.8±5.4 years) and 56 he...